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Mouse human orthologs database

Human Disease Genes and Their Cloned Mouse Orthologs

  1. ed the MGI database for Gene Ontology annotations. The Gene Ontology (GO)is a set of three structured vocabularies that describe the biochemical function, subcellular localization, or global biological process with which a gene product is associated.
  2. Three candidate human orthologs to OR genes that reside at the mouse P2 locus were identified from the GenBank database (HOR11-55A, HOR11-403A, and HOR11-610A) ().These three genes reside in a single human PAC (610i20) that maps to human chromosome 11p15.4, a human region syntenic to mouse chromosome 7E3
  3. Search ortholog: Search Search orthologs by any gene name, symbol, or synonym within human, fly, mouse, worm, and budding yeast organisms. Genetic Choose whether to return results from including genetic interactions within the network alignment
  4. MGI-Mouse Vertebrate Homology. Vertebrate Homology. MGI contains homology information for mouse, human, rat,and zebrafish. Access Data. Download a complete set of human, rat, and zebrafish Homology Classes for mouse genes obtained from the Alliance of Genome Resources. The report includes Chromosome and EntrezGene and OMIM IDs
  5. The Mouse Genome Database (MGD) has a unique and strategic role as a community resource for facilitating the use of the laboratory mouse for understanding the genomics underlying human biology and disease. MGD serves three major user communities: (i) biomedical researchers who use mouse experimentation to investigate genetic and molecular.
  6. coding genes (ALL) retrieved from the GENCODE database [19], we extracted the set of 2,472 one-to-one human orthologs of these essential mouse genes (EG, Figure 1A, Methods) and the non-overlapping set of 3,811 human orthologs of genes with known non-lethal phenotype (NLG) in homozygous mouse mutants (Table S6). If a null-mutant for a specific.
  7. ing of the MGI database resulted in 2,472 essential genes (EG) and 3,811 genes with non-lethal phenotypes (NLG) in human based on experimental evidence in mouse. Phenotypes that were observed only in a heterozygote state were disregarded

The approved symbols for the human, mouse and rat orthologs are shown, along with the chromosomal location, database IDs that are also links to the gene entry in HGNC, MGI, RGD and Entrez Gene, and the 'orthology criteria' used in defining these orthologous relationships INTRODUCTION. The Mouse Genome Database (MGD) is the community model organism knowledgebase for the laboratory mouse. MGD contains comprehensive information about mouse gene function, genotype-to-phenotype annotations, and mouse models of human disease ().The mission of the MGD is to advance the use of the laboratory mouse as a model system for investigating the genetic and genomic basis of.

Genomic analysis of orthologous mouse and human olfactory

  1. All mouse sequences and classification are now available through our KinBase database, where dynamic alignments with human orthologs and other kinases can be carried out. A related analysis of mouse kinases and phosphatases has been published by Forrest et al. We have looked at reasons for the differences between the two gene sets
  2. OrthoDisease: A Database of Human Disease Orthologs Kevin P. O'Brien,n Isabelle Westerlund, and Erik L.L. Sonnhammer Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden Communicated by A. Jamie Cuticchia One of the greatest promises of genome sequencing projects is to further the understanding of human disease
  3. Three candidate human orthologs to OR genes that reside at the mouse P2 locus were identified from the GenBank database (HOR11-55A, HOR11-403A, and HOR11-610A) (29). These three genes reside in a single human PAC (610i20) that maps to human chromosome 11p15.4, a human region syntenic to mouse chromosome 7E3. We have generated high.
  4. We recently identified a novel human sialic acid binding immunoglobulin-like lectin, Siglec-8, using mRNA from human eosinophils. To search for a mouse Siglec (mSiglec) ortholog of Siglec-8 and other mouse Siglec paralogs, we conducted public database searches with cDNA sequences of human Siglec-5 to -10 and identified two novel mSiglecs
  5. Researchers can also search the database using human gene symbols, such as a list of genes commonly mutated in a human cancer. The input list is mapped to corresponding mouse orthologs, and a summary table with links to relevant records in MTB is returned
  6. At present, we have curated and processed over 260 miRNA genes obtained from miRBase that have clear orthologs, along with >12 000 conventional genes obtained from the NCBI's Reference Sequence database with human-mouse orthologs. GenomeTrafac also allows for the creation of gene groups based on GO functional associations, pathways, diseases.

Choose different input and ouput species for Orthologs. Choose same input and output species for Paralogs. Set output species to All for Orthologs across all species. Adjust filters to optimize results. Enter Genes and/or Proteins (if list, use returns, not commas to separate; see help ) This set contains 756 human genes whose mouse orthologs have been experimentally deleted with the resulting phenotypes cataloged in the database of Mouse Genome Informatics (MGI). For the 594 human genes associated with mild diseases, we cannot infer gene essentiality, because mild disease After publishing the first draft sequence it was reported that the mouse, Mus musculus, genome was comparable in size and structure to the human genome and that 99% of mouse genes have human orthologs (Mouse Genome Sequencing Consortium, 2002). Having last shared a common ancestor 75 million years ago, and with the human genome filled with more.

Using the mouse and human genomes via the NCBI Reference Sequence database and the Sanger Institute miRBase, the system demonstrated the ability to identify validated transcription factor targets within promoter and distal genomic regulatory regions of both conventional and microRNA genes to all human and mouse orthologs and paralogs, and resolve situations where orthology assertions may be impossible to assign, e.g. olfactory receptor genes. We also aim to assign parallel nomenclature to human and mouse genes in ortholog pairs that currently have different approved symbols in each species I work with mouse data and have been using the Mouse_Gene_Symbol_Remapping_Human_Orthologs_MSigDB.v7.2.chip file for GSEA. I understand that sometimes multiple mouse gene symbols map to the same human orthologs Using the ENSEMBL (Hubbard et al. 2002) database (v man/mouse orthologs was used to identify human genes from 1.0) of confirmed proteins, we have searched for paralogs of our ortholog set that may have been duplicated at approxi- the human proteins for which mouse orthologs were avail- mately the same time as the divergence of human and mouse.

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Apr 26 17:39:58 2021. Complete table of the annotations represented in this image is provided below. Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature D2 Nucleic Acids Research, 2006, Vol. 00, Database issue obtained from the NCBI's Reference Sequence database (14) miRNAs (MIRN500 and MIRN448) and three of the with human-mouse orthologs Using a yeast 2-hybrid screen to identify Nedd4 ()-binding proteins in mouse, Murillas et al. (2002) cloned N4bp1 (), N4bp2 (), N4bp3, and N4bp4 (UBQLN2; 300264).They identified the human orthologs by database analysis. Full-length mouse and human N4BP3 contain 537 and 544 amino acids, respectively, and share 92% amino acid identity Toyoda et al. (2005) cloned chicken protogenin and identified the mouse and human orthologs by database analysis. Chicken protogenin contains 1,187 amino acids and has an extracellular domain, followed by 4 immunoglobulin domains and 5 fibronectin type III domains

Here, we use next-generation RNA sequencing (RNA-seq, for definitions of RNA-seq related terms, see supplemental data, available on the Blood Web site; see the Supplemental Materials link at the top of the online article) 18-23 to provide the first detailed analysis of the mouse platelet transcriptome. RNA-seq is also applied, for the first time, to human platelets, adding unprecedented depth. obtained from the NCBI's Reference Sequence database (14) with human-mouse orthologs. GenomeTrafac also allows for the creation of gene groups based on GO functional associa-tions, pathways, diseases or mammalian phenotypes. GenomeTrafac thus serves as both an analysis tool for any individual gene or miRNA for which there is an ortholog An accessible database for mouse and human whole transcriptome qPCR primers Bioinformatics. 2013 May 15;29(10):1355-6. doi: 10.1093/bioinformatics/btt145. Epub 2013 Mar 28. Authors Amit Zeisel 1 , Assif Yitzhaky, Noa Bossel Ben-Moshe, Eytan Domany. Affiliation 1 Department of Physics. This set contains 756 human genes whose mouse orthologs have been experimentally deleted with the resulting phenotypes cataloged in the database of Mouse Genome Informatics (MGI). For the 594 human genes associated with mild diseases, we cannot infer gene essentiality, because mild diseases may be due to mild mutations in essential genes or.

A table of human-to-mouse gene orthologs was obtained from Ensembl with detailed annotations (i.e. one-to-one, one-to-many and many-to-many, ortholog scores) and added to the MySQL database. SQL commands were used to link the orthologs and generate a gene ID centered non-redundant list of mouse-to-human orthologs and their corresponding protein. The mouse genome database (MGD) is the model organism database component of the mouse genome informatics system at The Jackson Laboratory. MGD is the international data resource for the laboratory mouse and facilitates the use of mice in the study of human health and disease. Since its beginnings, MGD has included comparative genomics data with a particular focus on human-mouse orthology, an. Data show the individual CYP expression in the different tissues as a percentage of the total amount of that CYP expressed in the designated tissues, as different primers were used for mouse and human orthologs. The overall patterns of expression in the selected tissues were fairly similar for human and mouse Family 1 CYPs, CYP2S1, and CYP2U1

Datasets - Home Page MIT CSAI

Hi, That is true, our database has been manually curated only considering human interactions. For mouse datasets, we have used orthologs. We have used it successfully in this way, but we can't guarantee about the accuracy of all interactions, we have not have the time to manually curate mouse interactions Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues . HOME ; Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissue

Process of generating human and mouse exon orthologs. A. Flow chart of orthologous exon database building. B. Exons with N (N > 1) putative exon orthologs were further verified if these N exons belonged to the same united exon. C. Identification of fused and split exons through analysis procedure from putative orthologous exons From the collection of 20,029 protein coding genes (ALL) retrieved from the GENCODE database , we extracted the set of 2,472 one-to-one human orthologs of these essential mouse genes (EG, Figure 1A, Methods) and the non-overlapping set of 3,811 human orthologs of genes with known non-lethal phenotype (NLG) in homozygous mouse mutants . If a. Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues. Choudhary D., Jansson I., Stoilov I., Sarfarazi M., Schenkman J.B. The present study compared the relative expression pattern of 10 orthologous CYP forms from families 1-4 in cDNA panels of human and mouse fetal and adult tissues Mouse orthologs were obtained from the Biomart database by using human gene names as query. The upregulated human genes and their mouse orthologs along with expression values are shown in Table S2 . Average values for each stage in human and mouse were calculated between the cells or embryos from the same biological stages

We used whole exome sequencing (WES) to investigate pathogenic and likely pathogenic (PLP) variants in 34 novel human-mouse orthologs HI genes, in 40 individuals from Cameroon and South Africa diagnosed with non-syndromic hearing impairment (NSHI), and compared the data to WES data of 129 ethnically matched controls. In addition, protein. The mammalian orthologs of zinc finger genes are biased towards the second peak both in human and mouse in the degree that gradually depends on the phylogenetic relatedness ().Thus, the metatherian (marsupial) orthologs are practically absent in the first peak of human and mouse, more so the monotreme orthologs ().For orthologs of olfactory receptors this asymmetry of peaks is much weaker, if. The orthologs in mouse were ''Down'' was further supported by a comparative microarray study identified using the Biomart database, resulting in 324 and 857 that showed consistent expression patterns between human and genes, respectively Using a larger dataset (2,400 human-rodent orthologs and 834 rat-mouse orthologs) and EST information, Duret and Mouchiroud [11] observed that tissue-specific genes, on aver-age, exhibited higher K A/K S ratios than genes expressed in most tissues (so-called 'housekeeping genes'). A more recent study of microarray data confirmed this finding. We hypothesize that the mouse orthologs of genes whose copy number change gives rise to the same human abnormality might also yield a similar phenotype when disrupted in mice. Thus, by bringing together a large number of disparate CNVs, we may be able to identify an unusually overrepresented phenotype among the affected genes' mouse orthologs

MGI-Mouse Vertebrate Homology - Mouse Genome Informatic

By EST database searching, Spiegel et al. (2002) identified full-length human CNTNAP5. By database analysis, Traut et al. (2006) identified 3 mouse orthologs of CASPR5. The deduced human protein shares 82 to 85% sequence identity with the mouse proteins. The human and mouse proteins contain an N-terminal signal peptide followed by a discoidin domain, 4 laminin G (LNS) domains, 2 EGF-like. These 67 human disease genes include genes related to neurological and eye disorders and cancer. We also present a list of the human disease genes and their cloned mouse orthologs found in two public databases, LocusLink and MGI. Allelic variant and gene functional information available in MGI provides additional information relative to these. the human phenotypes associated with GWAS-discovered loci to their corresponding mouse phenotypes, and we assembled a comprehensive list of mouse genes associated with these phenotypes. Then, we evaluated the extent of overlap between the mouse and human orthologs that have been associated with the same phenotype (Figure 1a)

Mouse Genome Database (MGD): Knowledgebase for mouse-human

This analysis revealed that half of all mouse and human orthologs have correlation in their expression patterns of 0.6 or better (Fig. 5A). Visualization of these highly correlated transcripts revealed striking similarity in the patterns of gene expression between mice and human (Fig. 5 B ) Model organisms have contributed substantially to our understanding of the etiology of human disease as well as having assisted with the development of new treatment modalities. The availability of the human, mouse and, most recently, the rat genome sequences now permit the comprehensive investigation of the rodent orthologs of genes associated with human disease Human-Mouse Orthologs. Entrez genes (20,273) were assayed on Affymetrix human HU133 plus v2 arrays, among which 16,646 genes had mouse orthologs according to the Mouse Genome Database , and 15,686 genes were assayed on Affymetrix mouse MOE430 arrays. Among 5,554 genes significantly changed in human conditions, 4,918 genes had mouse orthologs.

Gene expression was quantified for all human and mouse orthologs 40 as described above in 15 pairs of matching tissues. Mean FPKM was used when multiple individuals were sequenced for the same. curated orthologs occupied 25.4% of all computationally detected ortholog pairs (24122/94935) (release 4.1, 2007). Evola is a sub-database of H-InvDB (9,10,11), an

the sequence divergence between human and mouse during evolution. As shown in Table 1, only a small portion of exons could not beassigned. Exons/united exons are classified into groups with one single Figure 1 Process of generating human and mouse exon orthologs. A. Flow chart of orthologous exon database building. B. Exons with Selection of Candidate Orthologs. Chicken, human, and mouse candidate orthologs were selected as follows. We first collected all of the complete CDS of chicken mRNA from GenBank. Then using tBLASTn (Altschul et al. 1990, 1997) against the NCBI nr database, we found the highest scoring human and mouse hits for each chicken CDS. If the. IID (Integrated Interactions Database) is the first database providing tissue-specific protein-protein interactions (PPIs) for model organisms and human. IID covers six species (S. cerevisiae (yeast), C. elegans (worm), D. melonogaster (fly), R. norvegicus (rat), M. musculus (mouse) and H. sapiens ( The Mouse Genome Database: Genotypes, Phenotypes, and Models of Human Disease Carol J. Bult*, Janan T. Eppig, Judith A. Blake, James A. Kadin, Joel E. Richardso

While bat, camel, and human DPP4 support MERS-CoV infection, several DPP4 orthologs, including mouse, ferret, hamster, and guinea pig DPP4, do not. Previous work revealed that glycosylation of mouse DPP4 plays a role in blocking MERS-CoV infection. Here, we tested whether glycosylation also acts as a determinant of permissivity for ferret. Introduction MacGate is a publicly available resource focused on divergent gene regulation in human and mouse macrophages. The website displays expression data generated from a custom microarray, which we specifically collected and analysed to investigate divergent gene regulation in response to lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls that stimulates. sequence databases for human and mouse endoGPCRs and then performed sequence comparisons. This identified a unique gene set for each species and defined the human and mouse orthologs. In total, 338 endoGPCRs were identified in human and 301 in mouse. Sequence alignments indicated that 260 of these mole-cules are common to both species (Fig. 5) By searching a database for orthologs of mouse Acot genes, followed by RT-PCR of liver total RNA, Hunt et al. (2006) cloned human ACOT4. The deduced 421-amino acid protein has a putative catalytic site and a possible C-terminal peroxisome-targeting signal. Northern blot analysis detected ACOT4 transcripts of about 1.7 and 2.2 kb Read Test of the Binding Threshold Hypothesis for olfactory receptors: Explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912‐93, Protein Science on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips

High-affinity EREs found in the Mouse genome at a range a of -10kb to +5kb from mRNA 5'-ends (as mapped in NCBI built 30). Conserved EREs (EREs in gene orthologues with less than 2kb difference in their respective positions to the mRNA 5'-end in human and mouse orthologs). Warning : Please note that these files correspond to genome. mouse strain names and types, genes and allele type, and literature references. Researchers can also search the database using human gene symbols, such as a list of genes commonly mutated in a human cancer. The input list is mapped to corresponding mouse orthologs, and a summary table with links to relevant records in MTB is returned. MTB also. Of these, 72 (52.5%) were found in public databases (NCBI and SPTR) as previously described mouse orthologs and their function is known or inferred. The remaining 65 (47.5%) represent the best mouse to human match by sequence similarity but their function is not known, making them excellent candidate mouse orthologs We perused publicly available data (NHGRI database for human associations and Mouse Genome Informatics database for mouse models) and employed two alternative approaches for cross-species comparisons, phenotype- and gene-centric. A total of 293 single gene-phenotype human associations (262 unique genes and 69 unique phenotypes) were evaluated In total, 18 968 human genes have orthologs among 11 vertebrates (chimpanzee, mouse, cow, chicken, zebrafish, etc.), either computationally detected or manually curated orthologs. Evola provides amino acid sequence alignments and phylogenetic trees of orthologs and homologs

PPT - Human & Mouse Orthologous Gene Nomenclature (HUMOT

Architecture of tissue expression. In order to evaluate the global architecture of tissue expression between human, mouse and rat gene orthologs (hypothesis 1), we performed a Principal Component Analysis (PCA) on SET 1 and SET 2, each containing 2127 and 8954 orthologous gene clusters represented by 56 and 55 tissue types, respectively (Figure 1).. The Knockout Mouse Project (KOMP) is providing critical tools for understanding gene function and the genetic causes of human diseases. Coordinated by the International Mouse Phenotyping Consortium (IMPC), an international coalition will produce and phenotype a total of 5,000 knockout mice by 2016 The Reference Proteomes group provides complete non-redundant proteome sets for species chosen by the Quest for Orthologs group. It comprises 78 species that are publicly available and are generated using UniProtKB, Ensembl and Ensembl Genomes. The one gene one protein proteome sets are compiled from species sourced from complete. One of the greatest promises of genome sequencing projects is to further the understanding of human diseases and to develop new therapies. Model organism genomes have been sequenced in parallel to human genomes to provide effective tools for the investigation of human gene function. Many of their genes share a common ancestry and function with human genes, and this is particularly true for.

From Mouse to Human: Evolutionary Genomics Analysis of

IL8 (interleukin 8) is a protein-coding gene. Diseases associated with IL8 include mycobacterium marinum, and lung giant cell carcinoma. GO annotations related to this gene include interleukin-8 receptor binding and chemokine activity. An important paralog of this gene is PPBP. UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 The correlation coefficient measures the extent to which the human and mouse orthologous genes show the same tissue specificity. We further dissected the strength of this association for those orthologs with significant tissue specificity, i.e., those expressed in at least one tissue with p < 1E-6. As shown in Table 3, the results demonstrated that 40% of the qualified gene pairs showed a very.

The use of mouse sequences to identify human transcriptsOne thousand four hundred and fourteen mouse sequences that had no match to any full-length human cDNA were considered. Manual inspection of 672 randomly selected sequences indicated that 217 had no alignment to any full-length human mRNA sequence in the public database Mouse UniGene contains 895,000 sequences in 88,000 clusters, and rat UniGene contains 170,000 sequences in 37,000 clusters. A new UniGene resource, HomoloGene, includes curated and calculated orthologs and homologs for genes from human, mouse, rat, and zebrafish Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs) We identified orthologs by using bidirectional best hits, which is a widely used method. The E-value cutoff of Blast is 0.00001. As a result, 5006 B. mori genes were orthologs of human disease-associated genes, corresponding to 1612 kinds of human disorders. We classified human disease HORDE (The Human Olfactory Data Explorer) is a database of human Olfactory Receptors (ORs), the largest multigene family in vertabrates. ORs are G-Coupled Protein Receptors with a 7-transmembrane structure. The ORs are responsible for triggering the olfactory signal transduction pathway. You will find here information on the entire human OR.

Human and orthologous gene nomenclature - ScienceDirec

Video: Mouse Genome Database (MGD) 2019 Nucleic Acids Research

The Mouse Kinome - kinas

Time course studies identified TCDD-elicited differential expression of 515 human, 2371 mouse and 712 rat orthologous genes over the 24-h period. 28 orthologs were differentially expressed in response to TCDD in all three species CTGF (connective tissue growth factor) is a protein-coding gene. Diseases associated with CTGF include renal fibrosis, and diffuse scleroderma. GO annotations related to this gene include integrin binding and growth factor activity. An important paralog of this gene is WISP2. UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279 74645 Ensembl ENSG00000183508 ENSMUSG00000044468 UniProt Q5VWP2 Q5SSF7 RefSeq (mRNA) NM_017709 NM_001142952 RefSeq (protein) NP_060179 NP_001136424 Location (UCSC) Chr 1: 117.61 - 117.63 Mb Chr 3: 100.45 - 100.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein FAM46C also known as family with sequence similarity 46, member C is a protein that, in humans, is encoded by the. D) Similar to C), the time of the first breakpoint is highlighted in either blue or red for mouse and human orthologs. E) The first breakpoint times for mouse and human orthologs are represented as smoothed densities (bean plots) with overlaid raw data, the median, and a box representing the interquartile range The primary (unspliced) transcript of this non-coding RNA contains one or more snoRNA loci within intronic regions. Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Uhg5 using the Feature Mapper tool

Molecular analysis of human Siglec-8 orthologs relevant to

DEFA3 (Defensin Alpha 3) is a Protein Coding gene. Diseases associated with DEFA3 include Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1 and Bell's Palsy . Among its related pathways are Transcriptional misregulation in cancer and Innate Immune System . An important paralog of this gene is DEFA1 Complete information for C9orf72 gene (protein-coding), chromosome 9 open reading frame 72, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendiu In addition, the mouse ortholog (Mharp/Smarcal1) was cloned, and the Caenorhabditis elegans ortholog (CE-HARP) was identified in the GenBank database. Phylogenetic analysis indicates that the HARP proteins share a high level of sequence similarity to the seven motif helicase core region (SNF2 domain) with identifiable orthologs in other. NT5E (5'-nucleotidase, ecto (CD73)) is a protein-coding gene. Diseases associated with NT5E include calcification of joints and arteries, and intestinal tuberculosis. GO annotations related to this gene include nucleotide binding. Function: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

The Mouse Tumor Biology Database: A Comprehensive Resource

EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and calcium ion binding. An important paralog of this gene is GPR97. Function: Could be involved in cell-cell interactions NPY2R (Neuropeptide Y Receptor Y2) is a Protein Coding gene. Diseases associated with NPY2R include Cocaine Dependence and Nephronophthisis 4.Among its related pathways are Signaling by GPCR and Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics.Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and calcium channel regulator activity DRSC Functional Genomics Resources (DRSC-FGR) began as the Drosophila RNAi Screening Center (DRSC), founded by Prof. Norbert Perrimon in 2003, and the Transgenic RNAi Project (TRiP), founded by Prof. Perrimon in 2008. We have since grown into a functional genomics platform meeting the needs of the Drosophila and broader community by providing

GenomeTrafac: a whole genome resource for the detection of

IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.Among its related pathways are TNFR1 Pathway and PEDF Induced Signaling.Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity Citation for Human/Mouse/Rat p53 Agarose-conjugated Antibody R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions METTL26, previously designated C16orf13, is a protein-coding gene for Methyltransferase Like 26, also known as JFP2. Though the function of this gene is unknown, various data have revealed that it is expressed at high levels in various cancerous tissues. Underexpression of this gene has also been linked to disease consequences in humans

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DRSC - DRSC Integrative Ortholog Prediction Too

VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins. The tyrosinase enhancer is activated by Sox10 and Mitf in mouse melanocytes Pigment Cell Research 2007 20 3 173 184 10.1111/j.1600-0749.2007.00368.x 2-s2.0-34248643438 51 Schwahn D. J. Timchenko N. A. Shibahara S. Medrano E. E. Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-α and chromatin remodelers during. Introduction. The Treefam Perl object-oriented API is a set of Perl modules that provide high-level access to the data stored in the Treefam MySQL database. It has been designed to give easy access to entities commonly used in the Treefam project such as families, genes and trees. It aims at making automatic retrieval of particular data easy

Sigmar1 MGI Mouse Gene Detail - MGI:1195268 - sigma nonHuman brain bulk RNA-seq data (GTEx) analyzed in thisMarek TUTAJ | MSc IT | Medical College of Wisconsin(PDF) QuadBase: Genome-wide database of G4 DNARat Genome Database